3,3-dimethyl-octane from Physalis peruviana as promising anti-DENV via ADMET prediction of pkCSM open webserver

  • Muhammad Evy Prastiyanto Universitas Muhammadiyah Semarang
  • Rofiatun Solekha Universitas Muhammadiyah Lamongan
  • Laila Ainur Rohmah Universitas Muhammadiyah Lamongan
  • Yuanita Rachmawati Universitas Islam Negeri Sunan Ampel
  • Nur Sofiatul Aini Universitas Negeri Surabaya
Keywords: 3,3-dimethyl-octane, Physalis peruviana, dengue fever, DENV, Dengue


Dengue is caused by the dengue virus (DENV) and being prevalent in 100 tropical and subtropical countries including Indonesia. This disease is spread by Aedes mosquitoes. There is currently no clinically authorized medicine to treat the dengue fever. Physalis peruviana has ethnomedicine application and noted for its antioxidant activities. This study purpose to investigate the pharmacokinetics or ADMET of anti-DENV from leaf parts of P. peruviana. The phytoconstituents data were gathered from multiple sources. The drug property and ADMET prediction were assessed using pkCSM. Following online screening, 3,3-dimethyl-octane functioned as predictive anti-DENV therapeutic candidate. Further dry and wet lab studies are needed to validate this finding.


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How to Cite
Prastiyanto, M. E., Solekha, R., Rohmah, L. A., Yuanita Rachmawati, & Aini, N. S. (2024). 3,3-dimethyl-octane from Physalis peruviana as promising anti-DENV via ADMET prediction of pkCSM open webserver. Genbinesia Journal of Biology, 3(1), 23-30. https://doi.org/10.55655/genbinesia.v3i1.63